Abstract

Microwave-assisted synthesis of pyrido[4,3-d]pyrimidine derivatives and their biological evaluation

Author(s): W.A.Gad, H.D.Al-Harbi

In the present study, we report the important role of solvent-free conditions coupled with microwave activation and their advantages in heterocyclic synthesis. This eco-friendly approach, whichwas found application in facile organic synthesis, is applied to the rapid assembly of heteroatom organic compounds via cyclocondensation reactions. Combinatorial heterocyclic synthesis under solvent-free conditions is described having allowed to build a library of such heterocyclic compounds of pharmacological interest. Some of the discussed compounds show in vitro antimicrobial activity against Mycobacterium tuberculosis H37Rv (MTB) compared with some standard drugs.