Abstract

Induced pluripotent stem cells and its therapeutic potentials in regenerative medicine

Author(s): Indumathi Somasundaram, M.Dhanasekaran, Anand Kumar Arachimani, J.S.Rajkumar, Baskaran Mayakesavan

To avoid the complications of immune rejection of ES cells, diverse methods, such as somatic nuclear transfer (SCNT) and fusion of somatic cells with human ES cells, have been attempted to produce patient-specific pluripotent stem cells. Recent challenges are the process of generating induced pluripotent stem cells (iPSc) from adult somatic cells by certain defined factors through retroviral transfection method. These cells exhibited the properties of ES like cells in all aspects. Later, generation ofMouse iPS cells without viral vectors and generation of iPS cells withoutMyc are reported. iPSC cells offers a great therapeutic potentials in regenerative medicine by several findings, though therapeutic treatment of iPS is still at the earliest. However, continuous research on refining the novel therapeutic applications by circumventing the current problems is needed to make iPS cells a therapeutic potential for regenerative medicine.