Abstract
Improved preparation of formamidine intermediates used in the synthesis of anticancer agents gefitinib and erlotinib
Author(s): V.Chandregowda, G.Chandrasekara ReddyFormamidine intermediates have been prepared by cost effective reagents and using these formamidines, prepared anticancer agents Gefitinib and Erlotinib, approved by US FDA for the treatment of non-small-cell-lung cancer and pancreatic cancer. This convergent process reports an improvement in the procedure, yields and reaction times.
