Glycyrrhizin glabra as a bioenhancer for antibiotics

Author(s): K.S.Shobha, D.N.Gurucharan

Over usage of drugs in therapeutic treatments lead to the development of multiple drug resistance.So recently there has been a shift in global trend from Synthetic to Natural. Phytochemicals as medicines are esteemed all over the world as rich source of therapeutic agents. Combination of Glycyrrhizin glabra with commercial antibiotics exhibited promising bioenhancing activity by in-vitro Bioassay methods. Enhancement in antimicrobial activity of antibiotics like Ciprofloxacin, Gettifloxacin, Ofloxacin, Erythromycin (Antibacterial) and Flucanazole (Antifungal) was obtained. Butanol extract of glycyrrhizin glabrawas enhancing antibacterial antibiotics and water extract, antifungal antibiotic. 10%Butanol extract of glabra enhanced antibacterial activity of Ciprofloxacin by 4mm and Gettfloxacin by 7mm against Proteus vulgaris. Incase of Ofloxacin enhancement was observed in all bacteria like Bacillus subtilis (2mm), Proteus vulgaris (3mm) Staphylococcus aureus (1mm) Pseudomonas fluorescence (7mm). Erythromycin showed enhancement against Staphylococcus aureus (5mm) and Proteus vulgaris (2mm) while for Pseudomonas fluorescence, only combination exhibited zone of inhibition of 7mmbut not in antibiotic alone.Water extract of glabra showed enhanced antifungal activity in C.lipolytica (4mm) and C.neoformens (5mm), while for C.albicansbutanol extract showed maximumenhancement of 11mmin Flucanazole antibiotic.

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