Feature dimension reduction algorithm based prediction method for protein- protein interaction

Author(s): Tong Wang, Jihong Yan, Bicheng Ye, Jian Chen

Protein-protein interaction is essential to cellular functions. Knowing the protein-protein interaction often provides useful clues for finding its biological function and interaction process with other molecules in a biological system. In this paper, we describe a simple, novel approach to improve the accuracy of predicting protein-protein interaction. Here, dimensionality reduction algorithm is introduced to predict the proteinprotein interaction.Our jackknife test results indicate that it is very promising to use the dimensionality reduction approaches to cope with complicated problems in biological systems, such as predicting the protein-protein interaction.

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