Abstract

Enhancement to synthesize, design and dock of novel EGFR inhibitors containing pyrazolo[3,4-d]pyrimidine cores of expected anticancer activity

Author(s): Eman K.A.Abdelall, Rania B.Bakr, Mohamed K.Abdel-Hamid,Manal M.Kandeel

Several novel pyrazolo [4,3-d]pyrimidine series (5,6,9,10,12)were prepared by treatment of the hydrazide (4)with some different commercially available reagents such as isocyanates, isothiocynates, aromatic acids, a series of aromatic aldehydes and certain acid anhydrides respectively. All newly synthesized compounds were confirmed by elemental analysis, spectral data, and subsequent reactions whenever possible. Some of the prepared compoundswere screened for cytotoxic activity. Theirmolecular simulation docking to protein tyrosine kinase (EGFR), using Erlotinib (TarcevaTM) as a lead compound was also included.