Electromagnetic fields low levels altered the DNA infrared region in RA-differentiated SH-SY5Y neuroblastoma cells

Emanuele CalabrÃƒÂƒÃ‚ÂƒÃƒÂ‚Ã‚Â²; Salvatore Condello; Salvatore MagazÃƒÂƒÃ‚ÂƒÃƒÂ‚Ã‚Â¹; Riccardo Ientile

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BioTechnology: An Indian Journal
ISSN (PRINT): 0974-7435

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Abstract

Electromagnetic fields low levels altered the DNA infrared region in RA-differentiated SH-SY5Y neuroblastoma cells

Author(s): Emanuele Calabr�?�?�?�?�?�?�?², Salvatore Condello, Salvatore Magaz�?�?�?�?�?�?�?¹, Riccardo Ientile

Differentiated neuroblastoma cells (SH-SY5Y) were used to study the effects of lowstatic magnetic fields (SMFs) and extremely low frequency electromagnetic fields (ELF-EMFs) on the structure of DNA. Fourier Transform Infrared (FTIR) spectroscopy analysis showed that exposures to a SMF at 2mT and to a 50Hz EMF at 0.7mT produced peakÂÃ‚Â’s centroid shift and significant decreases of the phosphate absorption bands in the infrared region of DNA. The exposure also induced significant increase in reactive oxygen species (ROS) production in comparison to control confirming this scenario.