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Effect and mechanism of Oleanolic acid and Ursolic acid on small intestine peristalsis

Author(s): Peng Hai-Bing, Wang Rui-Xue,Tang Jun-Dong ,Wang Jian-Xing

Objective To explore the effects and its mechanism of oleanolic acid and ursolic acid on small intestine smooth muscle contractility in vivo and in vitro. Methods Ink propulsion method was used to observe oleanolic acid and ursolic acid in normal mice effects of small intestine motor. Small intestine smooth muscle specimens were established in a guinea pig in vitro. BL-420F biological systems was used to observe the effect of oleanolic acid and ursolic acid on isolated intestinal smooth muscle contraction amplitude, and atropine and diphenhydramine on its role. Results Oleanolic acid and ursolic acid increased the rate of ink propulsion dose-dependently. Both of them could increase contraction amplitude of isolated small intestinal smooth muscle of guinea pigs, and oleanolic acid has a stronger effect (P<0.05). Atropine and diphenhydramine could decrease the shrinkage effect of oleanolic acid and ursolic acid on intestinal smooth muscle. Conclusions Oleanolic acid and ursolic acid could promote intestinal peristalsis, expescially oleanolic acid. Its mechanism may be related to emotional cholinergic M receptor and histamine H1 receptor

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