Parası kalmadığı için otobüse binemiyordur ailesi porno izle ona daha yeni para gönderdiği için tekrar porno istemeye utanınca mecburen otostop çekmek için youporn çantasını alarak yol kenarına gelir etekli porno liseli türk kız yol kenarında dururken yanına yaklaşan porno kibar bir gencin onu gideceği yere kadar bırakmak porno izle istemesine çok mutlu olur arabaya bindiklerinde gideceği yer ile porno arabayı kullanan adamın gittiği yer arasında çok mesafe sex izle farkı olduğunu anlayan türk kız bu yaptığı porno indir iyilik karşısında arabada ona memelerini açar porno sapıklaşan adam yol kenarındaki hotelde durarak porno izle üniversiteli otostop çeken türk kızına odada sakso çektirip sikerDocking and Synthetic studies of Some Salicylic and Indomethacin Derivatives as Potential Inhibitors of Cyclin-dependent kinase 2| Abstract
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Abstract

Docking and Synthetic studies of Some Salicylic and Indomethacin Derivatives as Potential Inhibitors of Cyclin-dependent kinase 2

Author(s): Yaseen A. M.M Elshaier1*, Adel A. Marzouk2

The anti-inflammatory drug aspirin and its metabolite salicylic acid are reported to decrease the levels of cyclin A2 and CDK2 (cyclin-dependent kinase 2). Our objective in the present study is to design, synthesize and investigate salicylic acid derivatives (analogs and isosters) and indomethacin analogs which have the potential to inhibit CDK2 so that colon cancer cell growth can be arrested. The ability of several compounds to dock with CDK2 utilizing OpenEye software program were performed. Docking study showed that anthranilic acid interacts with PDB 1PYE through HB with Asp 145: A and Val 64: A. Different synthetic studies by using palladium catalyzed chemistry were adopted to prepare the starting materials for generation aza-indomethacin.


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Organic Chemistry: An Indian Journal received 521 citations as per Google Scholar report

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