Abstract
Design and synthesis of some novel thiophen analogues of indole as a potent antimicrobial and antioxidant agents
Author(s): J.S.Biradar, B.S.SasidharThis work reports an efficient synthesis of novel indole chalcones (3a-d) bearing thiophen ring by claisen-schimidt condensation and screening them for antimicrobial and in-vitro antioxidant (Free radical scavenging, total antioxidant capacity and ferric reducing antioxidant power) activities.Among the synthesized compounds (3b) and (3c) have shown promising antimicrobial activity and remaining compounds shown moderate activity. In all the test systems compounds (3b) and (3c) have exhibited excellent antioxidant activity. The structures of the synthesized compounds are assigned on the basis of elemental analysis, IR, 1H NMR, and mass spectral data.
