Abstract

Derivatives of doxorubicin for treatment of breast cancer

Author(s): Ronald Bartzatt

Breast cancer is a type of cancer that usually appears within the inner lining of themilk ducts or lobules. Treatmentwill include surgery, drugs (hormone therapy and chemotherapy), and radiation or combination thereof. This study presents eight drug derivatives of doxorubicin for treatment of breast cancer. These compounds are derived through substituent replacement onto the molecular scaffold of doxorubicin. Pharmaceutical properties of these compounds (inclusive of doxorubicin) such as 1-octanol/water partition Log P varied from0.567 to 4.137, rotatable bonds varied 5 to 12, polar surface area from195.084A2 to 206.08A2, andwater solubility 0.00873mg/L to 390mg/L. The number of oxygen and nitrogen atoms (hydrogen bond acceptors) remained constant at 12 for all compounds.Although violations of the Rule of five remained constant at three for all compounds, the variation of Log P and water solubility offers considerable and beneficial potential of this group of anticancer agents to enhance the anticancer activity of these anthracycline antibiotics. The variation of molecular substituents covalently bonded within the doxorubicin structure clearly allow advantageous analogs that may be effective pharmaceuticals for the clinical treatment of breast cancer.