Catalyst-free, one-pot three-component approach for regioselectiv synthesis of several substituted pyrazolo[3,4-b]pyridin-6(7H)-ones

Author(s): Azam Monfared, Manouchehr Mamaghani, Abbas Azimi Roshan, Hamzeh Kiyani

Aseries of 4-aryl-3-methyl-4,5-dihydro-1H-pyrazolo[3,4-b]pyridine­6(7H)- ones were synthesized via catalyst-free, one-pot three-component reaction of 5-amino-3-methyl-1H-pyrazole,Meldrum’s acid, and various aldehydes in refluxing ethanol. This protocol has merits of higher yields, easy-workup, and environmentally friendly approach.

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