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An efficient and facile synthesis of chloro, fluoro susbstituted chalcones, acetylpyrazolines and aminopyrimidines

Author(s): Kishor Kapadia, Sejal Solankee, Yogesh Prajapati, Hiral Patel, Pankit Solankee, Anjani Solankee

2-(4'-Chlorophenylamino)-4-(4'-fluorophenylamino)-6-(4'-acetyl phenylamino)-s-triazine (5) on treatmentwith different aromatic aldehydes yields chalcones (6a-e), which on cyclisation with hydrazine hydrate in presence of glacial acetic acid give acetyl pyrazolines (7a-e) and also on cyclisation with guanidine nitrate in presence of alkali give aminopyrimidines (8a-e). The constitutions of newly synthesized compounds have been established on the basis of their elemental analysis, IR and 1H NMR spectral data.

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