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A simple and efficient one pot biginelli condesation of pyrazolo[3,4-d]pyrimidine-ones/thiones

Author(s): S.H.Jarsania, V.H.Shah

The synthesis of pyrazolo[5,4-d]pyrimidines from5-isopropyl-2,4-dihydro- 3H-pyrazol-3-one, substituted benzaldehydes and urea or thiourea in ethanol in the presence of catalytic amount of conc. acid as a one pot biginelli reaction involving iminium cation is described. The constitution of the product has been supported by FT-IR, 1H NMR and mass spectral data.

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