Parası kalmadığı için otobüse binemiyordur ailesi porno izle ona daha yeni para gönderdiği için tekrar porno istemeye utanınca mecburen otostop çekmek için youporn çantasını alarak yol kenarına gelir etekli porno liseli türk kız yol kenarında dururken yanına yaklaşan porno kibar bir gencin onu gideceği yere kadar bırakmak porno izle istemesine çok mutlu olur arabaya bindiklerinde gideceği yer ile porno arabayı kullanan adamın gittiği yer arasında çok mesafe sex izle farkı olduğunu anlayan türk kız bu yaptığı porno indir iyilik karşısında arabada ona memelerini açar porno sapıklaşan adam yol kenarındaki hotelde durarak porno izle üniversiteli otostop çeken türk kızına odada sakso çektirip sikerA Progressive C-H Functionalization Technique Was Used to Complete the Whole Synthesis of K-252c| Abstract
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Abstract

A Progressive C-H Functionalization Technique Was Used to Complete the Whole Synthesis of K-252c

Author(s): Darrin Jones

A progressive C-H functionalisation approach was used to synthesise the bioactive indolocarbazole alkaloid K-252c (staurosporinone). The route uses direct functionalisation reactions around a simple arene core and includes two highly selective copper-catalyzed C-H arylations, a copper-catalyzed C-H amination, and a palladium-catalyzed C-H carbonylation, all of which contribute to the natural product framework's structural complexity. The indolocarbazole alkaloids have piqued the synthetic community's interest due to their fascinating biological features and potential as medicinal agents. K-252c, has garnered a number of elegant syntheses as a putative biosynthetic precursor and aglycone of staurosporine. The distinctive functional structure of the hexasubstituted arene framework drew us to these natural compounds because of their intriguing biological activity.


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Organic Chemistry: An Indian Journal received 471 citations as per Google Scholar report

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