A novel process for preparing substantially pure palonosetron hydrochloride, a 5-hydroxytryptamine subtype 3 receptor antagonist

Author(s): Ajay Singh Rawat, Neeraj Kumar, P.Venkateswarulu

A novel process for preparing pure Palonosetron hydrochloride (1), a 5- hydroxytryptamine subtype 3 receptor antagonist[1] is described. The new process is practical and commercially viable. The prior methods reported for preparing pure Palonosetron hydrochloride (1), are cumbersome like in few instances involving repetition of a chemical conversion step and in some instances involving repeated crystallization to reach to the right diastereomerically pure product, thus making the synthetic process practically less viable and less economical. The new method as developed by us provides a novel way to prepare pure palonosetron hydrochloride (1), by introducing catalytic amount of a suitable halogenating compound such as n-bromosuccinimide in the purification process which not only reduces the purification steps but also makes the process practical, robust and commercially viable.

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