A Multifunctional Probe For Selective And Sensitive Detection of Tryptamine And Fions Based on A Novel 5-Bromoindolehydrazone Anchored Diiodo Salicylaldehyde DerivativeAuthor(s): Stacy Miller
2-((5-bromo-1H-indol-2-yl) methylene) hydrazono) methyl)-4, 6-diiodophenol (BHDL), a novel indole-based chemosensor, has been created for the selective and sensitive detection of biogenic tryptamine and F ions. UV-visible/fluorescence spectroscopy was used to examine the binding affinity of probe BHDL for F/tryptamine (TryptA). Probe showed a substantial elevation in an emission band at 433 nm in the presence of TryptA, while the band at 555 nm suffered a blue shift with a decrease in intensity due to suppression of Excited State Intramolecular Proton Transfer (ESIPT) on BHDL. Due to the inhibition of ESIPT and deprotonation process began by the hydrogen bonding complex formation, complexation with F ions also causes an increase in a fluorescence band at 430 nm with the simultaneous disappearance of the emission band at 555 nm. Furthermore, Density Functional Theoretical (DFT) calculations were done to support the mechanism that worked on the probe BHDL when TryptA/F was present.