The Synthesis And Spectral Investigations Of New Derivatives Of 1,3,4-Oxadiazole, 1,3,4-Thiadiazole, And 1,2,4-TriazoleAuthor(s): Ahmet Cetin, Ahmet Cansiz1, Metin Koparir1, Cavit Kazaz
In this work, various compounds including ring 1,3,4-oxadiazole, 1,3,4- thiadiazole, 1,2,4-triazol were synthesized by cyclization of corresponding 1,4-disubstituted thiosemicarbazides from the reactions of hydrazide compounds with alkyl/aryl isothiocyanates. Furthermore, Mannich bases were prepared by thione tautomer form of 1,2,4-triazole and acid derivatives were prepared by thiole tautomer form of 1,2,4-triazole. The solvents, and reactants used in the study were purified according to literature. In addition, the synthesized compounds were also purified because of being importance of purify for characterization of organic compounds. Then these compounds were characterized by performing of melting point, elemental analyses, X-RAY, FT-IR, 1H-NMR (400MHz), and 13CNMR( 100MHz).