Succinate dehydrogenase is a mitochondrial marker enzyme. It is one of the hub linking oxidative phosphorylation and electron transport. It can provide a variety of electron in respiratory chain for eukaryotic and prokaryotic cell mitochondria. Its activity is generally used as indicators of the degree evaluation of the citric acid cycle run. This article summarizes the separation, active investigation, and the structure and nature of recent succinate dehydrogenase succinate dehydrogenase, succinate dehydrogenase applications. It aims to provide a reference for related research about succinate dehydrogenase.