The planning methods and operation modes of traditional distribution network are difficult to accommodate the high penetration of distributed energy resources (DERs). Active distribution network (ADN), based on the application of information and communication technology (ICT) and advanced metering infrastructure (AMI), is one of the alternative solutions. This paper proposes a multi-objective optimization method for ADN operation. Analyzing the DG active/reactive power decoupling control ability under the inverter-based interface mode and putting forward an ADN cross-regional energy utilization strategy, a ADN multi-objective optimization dispatching model is established aiming at the minimum of system operation costs, DREG curtailment and the network loss. It is solved with MOHS algorithm. The optimizing model is able to realize comprehensive benefit of ADN operation on the premise of prior utilization of renewable energy. It is suitable for multiple system operators and the relevant results could offer theoretical foundation and experience to the formulation of ADN operation dispatching strategy.