Abstract

Effects of distribution ratio of different groups between motherwort total alkaloids and astragalus total saponins on benign prostate hyperplasia modles in mices

Author(s): Mingsan Miao, Tisheng Cui, Lin Guo, Ming Bai, Peipei Tang

Objective:Explored effects of Distribution ratio of different groups between Motherwort total alkaloids (MTAs )and Astragalus Total saponins (ATS) on Benign Prostate Hyperplasia(BPH)modles in mices, screened optimal ratio of active ingredient of prevention and treatment of benign prostatic hyperplasia. Methods: Benign prostatic hyperplasia models induced by testosterone propionate in mices,measured wet weight of the prostate, prostate index, measured levels of Dihydrotestosterone(DHT) and pathological changes of prostate tissue morphology .Results: 7: 3,6:4,5:5 group of distribution ratio of different groups between MTAs and ATS significantly reduced wet weight,index of prostatic on benign prostatic hyperplasia in mice (P<0.01); 6:4,5:5 group of distribution ratio of different groups between MTAs and ATS significantly reduced levers of serum DHT (P <0.01); 6:4,5:5 group of distribution ratio of different groups between MTAs and ATS Pathological changes of benign prostatic hyperplasiaï¼Ã‚ˆP<0.01,P<0.05.. Conclusion: 6:4,5:5 distribution ratio of different groups between MTAs and ATS has better treatment on Benign Prostate Hyperplasia modles in mices