Analytical Chemistry: An Indian Journal
ISSN (PRINT): 0974-7419

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Adacolumn Therapeutic

Adacolumn Therapeutic selectively adsorbes granulocytes, monocytes/macrofages with the help of Fcγ and complement receptors. Approximately 65% of granulocytes and 55% of monocytes from the blood that passes through the column are adsorbed. However the count of blood cells will not go down below the healthy level as the entrapped activated cells are rapidly replaced by mobilisation of inactive, CD-10 negative leukocytes. This means that apheresis with Adacolumn has rather a qualitative than quantitative effect, i.e. activated leukocytes are replaced by inactive cells. Additionally, Adacolumn leukocyte adsorption is associated with sustained down-modulation of pro-inflammatory cytokines like TNF-u, IL-1v, IL-6 and IL-8 released by blood leukocytes together with down modulation of L-selecting and the chemokine receptor CXCR3 which mediate migration of leukocytes from blood into the inflammatory tissue. The blood passes through the Adacolumn where activated granulocytes and monocytes/macrophages are removed and the blood returns to the patient via a venepuncture in the opposite arm. The extracorporeal flow rate is 30 ml/min and the duration of one treatment session is 60 min. A small dose of heparin is employed as an anticoagulant this post marketing surveillance provides the most important ever efficacy and safety data on the Adacolumn therapeutic leucocytapheresis in patients with colitis. As a non-pharmacologic treatment for patients with active colitis most of whom were refractory to standard drug therapy.

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Analytical Chemistry: An Indian Journal received 378 citations as per Google Scholar report

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