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Abstract

Validated RP-HPLCmethod for the simultaneous determination of diclofenac potassiumand tizanidine hydrochloride in tablet dosage form

Author(s): P.Shanmuga Sundaram, S.Sesha Phanindra, N.Thiyagarajan,M.VijeyAanandhi

A simple, precise, accurate and rapid reverse phase high performance liquid chromatographic method was developed for the simultaneous estimation of Diclofenac Potassium and Tizanidine Hydrochloride in tablet dosage forms.AhypersilC18OctaDecylSilane (ODS) column 250mm4.6mm i.d, 5mparticle size in isocratic mode, withmobile phaseAcetonitril and Phosphate Buffer in the ratio of 55:45 v/v at pH-7were used. The flowrate was 1.5ml/min and effluentsweremonitored at 235 nm. The Retention time of Diclofenac Potassium and Tizanidine HCl were 4.75 and 8.78 respectively. The Linearity for Diclofenac Potassiumand TizanidineHClwere in the range of 10-50g/ml and 0.2-1.0g/ml respectively. Results of the analytical method were validated statically, and by recovery studies. The proposed method can be successfully used to determine the drug contents ofmarketed formulation.


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Analytical Chemistry: An Indian Journal received 378 citations as per Google Scholar report

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