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Utilization of Ammonium Ceric Sulfate and Methyl Orange for Indirect Spectrophotometric Determination of Atorvastatin in Pharmaceutical Dosage Form

Author(s): Alshabrawy A, Ahmed M and Nageh A

A simple, sensitive and reliable spectrophotometric method for determination of atorvastine (ASN) in pharmaceutical dosage form was developed by us. The method depends on oxidation-reduction reaction between atorvastatin and ammonium ceric sulfate (ACS) in acidic medium. The remaining unreacted ACS was allowed to react with methyl orange (MO) followed by measuring the remaining unbleached MO. Many parameters controlling this reaction have been studied and optimized. The method was validated over a concentration range of 3 μg/ml to 23 μg/ml by following ICH guideline. The limit of detection (LOD) and limit of quantitation (LOQ) were 0.83 μg/ml and 2.57 μg/ml respectively. The method was compared the reported method and it was found that there is no significance difference between the two methods the method was successfully applied to the quantitative determination of atorvastatin in its tablets.

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