Synthesis, characterization and antimicrobial activity of Cu(II), Co(II), Ni(II) and Zn(II) complexes derived from 1-(pyridin-2-yl aminomethyl) pyrrolidine-2,5-dione and 1-phenyl(pyridin-2-yl aminomethyl) pyrrolidine-2,5-dione

Author(s): D.Tamil Vendan1, S.Rajeswari1, S.Ilavenil2, G.Venkatesa Prabhu1*

Complexes of Cu(II), Ni(II), Co(II) and Zn(II) have been synthesized using theMannich base formed by the condensation of 2-amino pyridine, formaldehyde /benzaldehyde and succinimide.Microanalysis, molar conductance, magnetic susceptibility, IR, UV-Vis, 1H NMR, 13C NMR studies have been carried out to determine the structure of the complexes. From the data, it is found that all the complexes possess octahedral geometry.All the title complexes were screened for antimicrobial activity by the well diffusion technique usingDMSOas solvent. Theminimuminhibitory concentration (MIC) values were calculated at 37C for a period of 24 h. It has been found that all the complexes are antimicrobial active and showhigher activity than the free ligand.

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