Abstract

Spectrophotometric, atomic absorption spectrometric and conductometric methods for determination of naftidrofuryl oxalate and propafenone HCl

Author(s): Mervat M.Hosny, Magda M.Ayad, Hisham E.Abdellatef, Yassmin A.Sharaf

Four methods are described for the determination of naftidrofuryl oxalate and propafenone HCl based on the formation of their ion-associates with ammoniumreineckate. Pink coloured complexes were determined spectrophotometrically at ëmax 525 in the range of 0.6-3.8 and 0.4 -3.2 mg ml-1 for naftidrofuryl oxalate and propafenone HCl respectively. The second and third methods involved direct atomic absorption spectrometric (AAS) and indirect (AAS) by measuring the excess metal ion present in supernatant solutions in the range of 80-320 and 40-280 µg ml-1for naftidrofuryl oxalate and propafenone hydrochloride for both methods. The fourth method included conductometric titration using ammonium reineckate as titrant, the studied drugs were evaluated in double distilled water in the range 20-140 and 40-140 µg ml-1. For naftidrofuryloxalate and propafenone. Various experimental conditions were established, results obtained showed good recoveries with relative standard deviation of (0.54, 0.52), (0.42, 0.65), (0.92, 0.39)and (0.48,0.31) for spectrophotometric, direct, indirect (ASS) and conductometric methods for naftidrofuryl oxalate and propafenone hydrochloride respectively. The proposed procedures were applied successfully to the analysis of these drugs in their pharmaceutical formulations. Results were favorably comparable to the official methods. The molar combining ratio reveal that (1:1) (drug: reagent) ion associates were formed.