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Abstract

Spectrophotometric and TLC-densitometric determination of dantrolene sodium in presence of its acid degradates

Author(s): Samah S.Abbas, Hebat Allah M.Essam, Mohammad G.El-Bardicy

This work is concerned with determination of dantrolene sodium in presence of its acid degradates in bulk and in pharmaceutical formulations by two different techniques. The first one is the application of first derivative spectrophotometric technique which permits selective determination of dantrolene sodiumat ë 420.9 nm without interference. BeerÂ’s law was obeyed in the concentration range of 2-22 µg mL-1 with mean percentage recovery of 99.67 ± 1.018. The second method depends on the quantitative densitometric evaluation of thin layer chromatogram of dantrolene sodium with ultraviolet detection at 388nm using chloroform/ acetone/ glacial acetic acid (85:15:1 by vloume) as a developing systemwith no interference of its acid degradates. The calibration graphwas linear in the range of 0.1-0.6 µg/ band. The suggested methods were used to determine the drug in presence of its acid degradates in both pure form and commercial capsules. The obtained results were statistically compared with those obtained by the manufacturerÂ’s method, showing no significant difference with respect to accuracy and precision.


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Analytical Chemistry: An Indian Journal received 378 citations as per Google Scholar report

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