Abstract

Solifenacin succinate estimation in bulk and pharmaceutical preparations by visible spectrophotometry

Author(s): Korupolu Raghubabu, N.Mohan Rao, Buridi Kalyana Ramu, C.Ramdas

Two simple, sensitive and cost effective visible spectrophotometric methods (M1-M2) were described for the estimation of Solifenacin succinate in bulk and dosage forms. Method M1 involves Internal salt formation of aconitic anhydride, dehydration product of citric acid [CIA] with acetic anhydride [Ac2O] to formcolored chromogen with an absorptionmaximum of 580 nm without using any puffer solution and the method M2 is based on the formation of green colored coordination complex by the drug in free base with cobalt thiocyanate which is quantitatively extractable into nitro benzene with an absorption maximum of 625 nm. BeerÂÂ’s law obeyed in the concentration range of 16-48µg/ml and 20-100 µg/ml for methodM1 andM2 respectively. Commercial tablets were analyzed and the results are statistically compared with those obtained by the reference UV method and validated by recovery studies. The results are found satisfactory and reproducible. No interference was observed from the usually existing additives in pharmaceutical formulations.