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Abstract

Simultaneous estimation of alfuzosin hydrochloride and dutasteride by validated RP -HPLC method

Author(s): D.B.Patel

This research paper describes validated reverse phase liquid chromatographic method for the simultaneous estimation of alfuzosin hydrochloride and dutasteride in bulk drug and tablets. The HPLC separationwas achieved on a Phenomenex C18column (250mmid, 4.6mm, 5 µm particle size) using methanol:0.02Mammoniumacetate buffer (85:15, v/v), pH9.5 adjustedwith 0.1%w/v triethylamine, asmobile phase at a flowrate of 1.0 ml/min. Quantification was achieved with photo diode array detection at 274 nmover the concentration range 1–50 µg/ml and 1-20 µg/ml with mean % recovery of 98.92% and 99.76% for alfuzosin hydrochloride and dutasteride, respectively by proposed RPLC method. Proposed method is simple, precise, accurate, sensitive and applicable for the routine simultaneous estimation of alfuzosin hydrochloride and dutasteride in bulk drug and in formulations.


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