Abstract

Simple spectrophotometric methods for the determination of lovastatin in pharmaceutical formulations

Author(s): Y.Suneetha, N.Saritha, N.Krishnaiah, N.V.S.Naidu, K.Saraswathi

Two new simple, sensitive selective, rapid economical spectrophotometric methods (A&B) were developed for the determination of Lovastatin in pharmaceutical formulations. Method A and B are based on the reaction of the drug giving an ion association complex formation with acidic dyes of the bromothymal blue (BTB) and methyl orange(MO) at pH 4.3 which are extractable into chloroform to forma colored product, with the maximumabsorption at 430 and 520 nm. BeerÂ’s law is obeyed in the concentration range of 10-50 µg/ml and 1.0-5.0 µg/ml for Methods A and B, respectively. Both the methods (A&B) have been successfully applied for the assay of the drug in pharmaceutical formulations. No interference was observed from common pharmaceutical adjuvants. The reliability and the performance of the proposed methods were established by point and interval hypothesis tests and through recovery studies. 