All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Abstract

Selective spectrophotometric methods for quantification of sitagliptin and metformin

Author(s): Safa????????????????????????????????a M.Riad, Mamdouh R.Rezk, Ghada Y.Mahmoud, Abdel-Aziz El Bayoumi Abdel Aleem

Four simple, accurate and precise spectrophotometric methods were developed and validated for the simultaneous determination of sitagliptin phosphate (STA) and metformin HCl (MTF) in their mixture. Among the developed methods were first derivative, second derivative, dual wavelength and ratio subtraction methods. The first derivative spectrophotometricmethod was used for the determination of STAin the range of 25-500 ìg mL-1, while the second derivative spectrophotometric method was used for the determination of STAin the range of 25-500 ìg mL”1 in addition to MTF in the range of 2.5-35 ìg m-1. The dual wavelength and ratio subtraction methods were used for the determination ofMTF in the range of 5-30 ìg mL-1and 2.5-30 ìg mL-1, respectively. The results were statistically compared with the reference ones. The developed methods were proved to be selective and accurate for the quality control and routine determination of the cited drugs in their mixture and in their pharmaceutical formulations.


Share this       
Awards Nomination 20+ Million Readerbase

Table of Contents

Google Scholar citation report
Citations : 378

Analytical Chemistry: An Indian Journal received 378 citations as per Google Scholar report

Indexed In

  • CASS
  • Google Scholar
  • Open J Gate
  • China National Knowledge Infrastructure (CNKI)
  • CiteFactor
  • Cosmos IF
  • Electronic Journals Library
  • Directory of Research Journal Indexing (DRJI)
  • Secret Search Engine Labs
  • ICMJE

View More

Flyer