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Abstract

RP-HPLCmethod for the analysis ofRoxithromycin in bulk and pharmaceutical dosage forms

Author(s): K.Ravi Sankar, Prafulla Kumar Sahu, M.Mathrusri Annapurna

A rapid and sensitive reverse phase high performance liquid chromatographic method was developed for the determination of Roxithromycin present in bulk and pharmaceutical dosage forms. Roxithromycin was chromatographed on a reverse phase C18 column with a mobile phase consisting of acetonitrile and 0.05 M potassium dihydrogen phosphate buffer (pH4.2) in the ratio of 70:30 v/v. Themobile phasewas pumped at a flowrate of 1.5 ml/min. Valdecoxib was used as an internal standard and the eluents were monitored at 207 nm. The retention time of the drug was 4.0 min.With thismethod, linearitywas observed in the range of 10-2000g/ml. The LOD and LOQ were found to be 0.172g/ml and 0.461g/ml, respectively. The method was found to be applicable for analysis of drug in tablets. The results of the analysis were validated statistically.


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Analytical Chemistry: An Indian Journal received 378 citations as per Google Scholar report

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