Novel visible spectrophotometric method development for the determination of oseltamivir phosphate in capsules using NQS as a chromogenic reagent

Author(s): B.Kalyana Ramu, M.Syam Bab, U.Viplava Prasad

A direct, simple and sensitive visible spectrophotometric method is described for the assay of oseltamivir phosphate in pure and capsule forms. The method is based on the formation of yellowish brown colored species by the drug with Folin reagent and exhibits absorption maxima at 453 nm. Regression analysis of Beer-Lambert plots showed good correlation in the concentration ranges (16-48) µg/ml. The proposed method is applied to commercial available capsules and the results are statistically compared with those obtained by the UV reference method and validated by recovery studies. The results are found satisfactory and reproducible. The method is applied successfully for the estimation of the Oseltamivir phosphate in the presence of other ingredients that are usually present in dosage forms. The method offers the advantages of rapidity, simplicity and sensitivity and normal cost and can be easily applied to resource-poor settings without the need for expensive instrumentation and reagents

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