Abstract

New Spectrophotometric Methods For The Determination Of Aripiprazole In Pure Form And In Pharmaceutical Formulations

Author(s): Dannana Gowri Sankar, Marothu Vamsi Krishna

Three simple spectrophotometric methods (A, B and C) are described for the determination of aripiprazole (APZ) in pure form and in pharmaceutical formulations. Method A is based on the oxidative coupling reaction between APZ with 2, 6- dichloroquinone-4-chlorimide (DCQC) and the color developed was measured at 620 nm. Method B is based on the replacement of sulfonate group of 1, 2 - napthoquinone- 4- sulphonic acid (NQS) by an imino group of APZ producing a colored product which absorbs maximally at 485 nm. Method C is based on the formation of a colored complex between APZ and sodium nitroprusside (SNP) in presence of hydroxyl amine and alkali, which exhibits maximum absorption at 515 nm. The optimum experimental parameters for the color production are selected. Beer’s law is valid with in a concentration range of 2.5 - 12.5 μg/ml for methods A, B and 5-40 μg/ml for method C. The results obtained are reproducible and are statistically validated and found to be suitable for the assay of APZ in pharmaceutical formulations.