All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Abstract

Investigation of the interaction between valsartan and bovine serum albumin

Author(s): Mariam Gaied, Lobna Abdel-Aziz, Laila Abdel-Fattah, Amira El-Kosasy

The interaction of valsartan (VLS), an angiotensin II receptor antagonist, with plasma and bovine serum albumin (BSA) has been investigated at physiological acidity (pH 7.40) by spectroscopic (UV spectrophotometry and fluorescence) techniques. The effect of BSA on UV absorption spectra of valsartan was monitored at three concentration levels of BSA. The binding parameters of VLS-BSA were calculated using non-linear regression analysis of the Scatchard plot. The binding percentages were calculated at different dilution folds of plasma. A strong fluorescence quenching reaction of VLS to BSAwas observed. The binding constants ofVLS with BSA at 288, 298 and 309 K were calculated as 2.624ï‚´107, 2.431ï‚´107 and 2.254ï‚´107 M-1, respectively. The thermodynamic parameters, Hï‚° and Sï‚° were obtained to be -5.35 ± 0.096 kJ mol-1 and 123.49 ± 0.32 J mol-1 K-1, respectively, indicating the presence of hydrophobic forces between VLS and BSA.


Share this       
Awards Nomination 20+ Million Readerbase

Table of Contents

Google Scholar citation report
Citations : 378

Analytical Chemistry: An Indian Journal received 378 citations as per Google Scholar report

Indexed In

  • CASS
  • Google Scholar
  • Open J Gate
  • China National Knowledge Infrastructure (CNKI)
  • CiteFactor
  • Cosmos IF
  • Electronic Journals Library
  • Directory of Research Journal Indexing (DRJI)
  • Secret Search Engine Labs
  • ICMJE

View More

Flyer