Abstract

Development of new spectrophotometric methods for the estimation of levosalbutamol in tablet dosage forms

Author(s): P.Thulasamma, R.Kishore Kumar, P.Venkateswarlu

Two simple, sensitive and cost-effective spectrophotometric methods have been developed for the estimation of levosalbutamol(LSB) in bulk drug and pharmaceutical dosage forms. Methods were based on the formation of reddish yellow colored and bluish green colored chromogens, which were measured at 555 nmand 425 nm, respectively and are stable formore than 12 hours in case of both methods. Beer’s law is obeyed at concentration of 20- 100 gmL-1 inmethod ‘A’and 30-110 gmL-1 inmethod ‘B’atwavelength of maximumabsorbance. Common excipients used as additives in pharmaceutical preparations do not interfere in the proposed method. The results obtained with the proposed methods are in good agreement with labeled amounts when tablet dosage forms were analyzed.