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Abstract

Development and validation of spectrofluorimetric method for the estimation of Flupirtine maleate in bulk drug and pharmaceutical dosage form

Author(s): Umang Shah, Mansukh Kavad, Manan Raval

Spectrofluorimetric analysis for the quantification of Flupirtine maleate belongs to centrally acting non-opioid analgesic in pure and pharmaceutical dosage form is described. The calibration curves were found linear between fluorescence intensity and drug concentration in the range of 50- 300 ng/mlwith coefficients of determination above 0.9992 for all the analytes. Fluorescence wasmonitored at 388 nmemission wavelength while excited at 320 nm. Themethod recoverieswere higher than 99%. The%RSD value of intra- and interday variation coefficients were observed less than 2%. The limits of detection (LOD) and limit of quantification (LOQ) were found in the range of 6.216 ng/ml and 18.839 ng/ml, respectively.Thus, themethod will be applied successfully to the determination of the cited drugs in pure and pharmaceutical dosage with good accuracy and precision. These methods are simple, accurate and rapid; those require no preliminary separation and therefore can be used for routine analysis of Flupirtine maleate in quality control laboratories. 2013 Trade Science Inc. - INDIA.


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Analytical Chemistry: An Indian Journal received 378 citations as per Google Scholar report

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