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Abstract

Development and validation of new RP-HPLC method for the estimation of furazolidone in bulk and solid dosage form

Author(s): Dhirender Singh Mittan, Pradeep Kumar, S.P.Venkatesh Prasad, Vikas maurya, Naresh Chandra Joshi, Lalit Kumar

Method is A Rapid, precise, accurate, specific and simple HPLC method developed for estimation of Furazolidone.AHigh performance liquid chromatograph using Phenomenex-Luna RP-18(2), 2504.6mm, 5 mcolumn, with mobile phase having a composition of Methanol: Acetonitrile [90:10 (v/v)] was used. The flow rate of 1.0 ml min-1 and effluent was detected at 259 nm. The retention time of furazolidonewas 2.770minutes. Linearitywas observed in concentration range of 2-18g/ml. Atorvastain was used as internal standard (IS), the retention timewas found to be 2.196minutes. The conc of internal standard used was 8 g/ml in each dilution The mean recoveries were found in the range of 99-100 %. The proposed method was validated for various ICH parameters like linearity, limit of detection, accuracy, precision, ruggedness, robustness, and system suitability.


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Citations : 378

Analytical Chemistry: An Indian Journal received 378 citations as per Google Scholar report

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