Abstract

Carbon paste and PVC electrodes for the potentiometric determination of trimetazidine, amantadine and ranitidine

Author(s): Elmorsy Khaled, Manal.S.Kamel, H.N.A.Hassan

Carbon paste and PVC electrodes were constructed for the potentiometric determination of trimetazidine(TRMZ), amantadine(AM) and ranitidine(RN). Differentmethods for electrode fabrication(including formation of the ion pair in situ, soaking of the electrode in the ion pair aqueous solution, in addition to the classicalmodification of the electrode matrix with the ion pair) are described for both CPE and PVC electrodes. The electrodes exhibitNernstian slopes 30.26±1.79, 58.2±1.5 and 59.5±3.3 for CPE and 28.8±1.27, 60.5±0.65& 54.6±3.4 for PVC corresponding to TRMZ, AM and RN, respectively. Comprehensive investigation of the electrode matrix compositions for each drug takes place as well as the effect of pH, temperature and life span. CPE electrodes showed superpriority when compared with the PVC regarding the ease of fabrication and regeneration as well as the short response time and long life time. The proposed electrodes were successfully applied for the determination of the TRMZ,AM and RN in pure solutions and dosage forms with good accuracy and precision.