An HPLC method for the determination of busulfan in biological samples

Author(s): M.A.Navarro Moreno, A.Moreno Galvez, L.Moreno Galvez

An HPLC analytical method for assessing plasma busulfan rat has been developed. Thismethod uses 1,5-Bis (metansulfoniloxy) pentane, as internal standard, dimethylformamide (DMF) as solvent, Tri Butyl n Phosphine as an antioxidant and 8Mercaptoquinoline (Q) as a reagent.We have evaluated the accuracy, reproducibility and speed, with satisfactory results.

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