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Abstract

A validated high performance thin layer chromatographic method for simultaneous estimation of aspirin and clopidogrel in pharmaceutical dosage form

Author(s): Mrinalini C.Damle, Amol O.Bajaj, Asma Y.Saudagar, Nikhil T.Awatade, Ruchira K.Makawana, Padmanabh B.Deshpande

A simple, accurate, precise and rapid high-performance thin-layer chromatographic method for simultaneous determination of Aspirin and Clopidogrel Bisulphate, both as a bulk drug and in pharmaceutical formulations was developed and validated. The method employed aluminum TLC plates precoated with silica gel 60F254 as the stationary phase. The solvent systemconsisted ofToluene:Methanol: Chloroform(5:3:2, v/v/v) asmobile phase. Densitometric analysis of Aspirin and Clopidogrel Bisulphate was carried out at 226 nm. The system was found to give compact spots for Aspirin (Rf 0.4 0.02) and Clopidogrel Bisulphate (Rf 0.85  0.01). The linear regression analysis data showed good linear relationship in the concentration range 600-1600 ng per spot for Aspirin and 1200-3200 ng per spot for Clopidogrel Bisulphate. The method was validated for precision, accuracy, specificity and robustness. The method has been successfully applied to the analysis ofmarketed formulation.


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Citations : 378

Analytical Chemistry: An Indian Journal received 378 citations as per Google Scholar report

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