All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Abstract

A validated GC method for estimation of process related impurities in 3-(N-methyl-N-pentylamine) propionic acid hydrochloride (ISB), a precursor of ibandronate sodium

Author(s): K.Hima Bindu, I.Ugandar Reddy, A.Rammohan Rao, A.Madhuri, Y.Anjaneyulu, M.V.Suryanarayana

The present paper describes the development of a gas liquid chromatographic method for advanced intermediate of Ibandronate sodium (ISB) in the presence of its impurities. As the molecule is a hydrochloride salt, the sample preparation was critical for the quantification of known and unknown impurities. Successful separation of ISB from the synthetic impurities achieved on aAT-5, 30 m × 0.53 mm, 5µ column. The developed GC method was validated with respect to linearity, accuracy, precision, ruggedness and robustness. To the best of our knowledge, a validated GC method which separates all the impurities disclosed in this investigation was not published elsewhere.


Share this       
Awards Nomination 20+ Million Readerbase

Table of Contents

Google Scholar citation report
Citations : 378

Analytical Chemistry: An Indian Journal received 378 citations as per Google Scholar report

Indexed In

  • CASS
  • Google Scholar
  • Open J Gate
  • China National Knowledge Infrastructure (CNKI)
  • CiteFactor
  • Cosmos IF
  • Electronic Journals Library
  • Directory of Research Journal Indexing (DRJI)
  • Secret Search Engine Labs
  • ICMJE

View More

Flyer