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Abstract

A Stability Indicating Assay Method For Verapamil Tablets By High Performance Liquid Chromatography For Stability Studies

Author(s): Monika Jain, S.N.Shrivastava

A simple and stability indicating HPLC assay procedure had been developed and validated for verapamil tablets stability samples. The mobile phase consisted of buffer (1.4g Na2HPO4/1000ml water pH 7.0 by H3PO4): acetonitrile: in the ratio of (50:50) isocratic elution is carried out under ambient condition at flow rate of 2.0 ml min-1 and detector was set at 232 nm. The column selected was thermohypersil, C18, 5μm packing, 4.6 mm x 250 mm and injection volume was 20 μl. The procedure separated verapamil and potential degradation product. The retention time of verapamil is 13.2 min and asymmetry was 1.55. The instrument precision obtained was 0.27 %.The procedure provided a linear response in the range of 50 - 150 % of target concentration (r = 1.000). Forced degradation study shows, response of main drug is reduced in acid, alkali and peroxide degradation. The method was validated for accuracy, robustness and solution stability was obtained up to 25 hrs.


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Analytical Chemistry: An Indian Journal received 378 citations as per Google Scholar report

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