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Abstract

A rapid novel RP- HPLC stability indicating assay method development and validation of simultaneous determination of Sumatriptan Succinate and Naproxen Sodium

Author(s): D.Vivekananda Reddy, P.Sreelatha, B.Rama Devi

A simple, precise, specific, accurate and linear reversed phase liquid chromatographic method was developed for the simultaneous determination of Sumatriptan Succinate and Naproxen Sodium in Pharmaceutical dosage forms. The method was precise, linear and accurate over a range of 0.4-6.4 mg/ml for Sumatriptan Succinate and 0.076-1.2mg/ml forNaproxen Sodium, at a detection wavelength of 280 nm and a gradient flow program. The method was also found to be stability indicating with all the known impurities of both Sumatriptan Succinate and Naproxen Sodium and also the degradents of the drug product well separated from the two analyte peaks. The method is validated for specificity, accuracy, precision, linearity and robustness in accordance with ICH guidelines.


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Citations : 378

Analytical Chemistry: An Indian Journal received 378 citations as per Google Scholar report

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