Transitionmetal complexes of tridentate schiff base ligand : synthesis, spectral characterization and antimicrobial properties

Author(s): A.A.Kachare, S.A.Kumbalpuri, S.G.Shankarwar,T.K.Chondhekar

The new Mn(II), Fe(III), Co(III), Ni(II), Cu(II), Zn(II) solid complexes of newly synthesized Schiff base ligand (E)-4-Chloro-N’-(l-C4-hydroxy-1- methyl-2-Oxo-1,2-dihytroquinoin-3-yl)ethylidene) benzohydrazide were synthesized, and characterized on the basis of elemental analysis, magnetic susceptibility, FTIR,1H NMR spectra, mass spectra, X-ray powder diffraction and UV visible spectral data. Form the analytical data the stiochitometry of metal complex has been found to be the 2:1 ligand to metal ratio. Therefore the complexes may be formulated as [M(L2)], where M=Mn(II), Fe(III), Co(III), Ni(II), Cu(II), and Zn(II). On the basis of spectral data octahedral geometry has been assigned to the Mn(II), Fe(III), Co(III), Ni(II), Zn(II), complexes, while Cu(II) complex has distorted octahedral geometry. The ligand and their metal chealets have been screened for their antibacterial activity using the Agar cup method at fixed concentration of 1% against microbial strains, Eschershia coli, Salmonalla typhi, Staphylococcus aureus, Bacillus subtilis. The antibacterial screening of ligand and it’s complexes illustrates that all the ligands and complexes seems to be inert towards the E. coli. The compexes show higher activity than ligand against Staphylococcus aureus and Bacillus subtilis. Antifungal activity of ligand and complexes were tested in vitro against fungi that is Aspergillus niger, Penicilium chrysogenum, Fusarium moniliforme, Aspergillus flavus by poison plate method using potato dextrose agar medium at fixed (1%) concentration. Ligand does not show fungal activity but it’s complexes show better activity in Co(III) complex show higher activity than other complexes. It suggests that the incorporation of metal ion in the ligand results in increasing the antimicrobial activity. X-ray diffraction data suggests monoclinic structure of. Co(III) complexes. Where Mn(II), Fe(III) and Zn(II) complexes show triclinic nature.

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