The Colorado potato beetle (Leptinotarsa decemlineata Say), is a major pest of potatoes in Uzbeksitan and many other parts of the world. Decreasing crop losses aused by the Calorado Potatoes Bettle and larvae feed on the foliage and stems of potato plants, resulting in poor yields and plant death. We observed the Efficiency of biological in Antibac Uz of biopesticide against Colorado potato beetles on Potatoes. Determination the Efficiency of biological inAntibac Uz of biopestiside against Colorado potato beetles a field and laboratory experiments have been conducted ÂAgro farmer family Shalola Abdurakhim YusupovÂ, disrtict Qibray, Province Tashkent. We use Antibac Uz bioinsecticide 5.0 liter per hectare spending in the days of 3, 7, 14, 21 against Colorado potato beetles after inoculation showed effect of 6,6; 31,6; 44,8; 37,5%. The against to larvae was better in fact 35,4; 54,7; 56,7; 68,8%. Once we use Antibac Uz biopesticide 6.0 liter per hectare in the days of 3, 7, 14, 21 pesticide showed effect of 38, 2; 41, 9; 56,0; 48,1%.