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, Volume: 10( 1)

A Review on Determination of Prinivil Using HPLC

Shiva S , Department of Pharmacy, Vignan Institute of Pharmaceutical Technology, Visakhapatnam, Andhra Pradesh, Tel: 9490074511; E-mail:

Received: September 15, 2016; Accepted: September 19, 2016; Published: September 24, 2016

Citation: Shiva S. A Review on Determination of Prinivil Using HPLC. ChemXpress. 2016;10(1):117.


Present review determines the analytical ways for the quantitative determinations of Prinivil (ACE inhibitor) by actinic radiation spectrophotometry and superior liquid natural process. Pharmaceutical analysis of Prinivil needs effective analytical procedures for QC internal control analysis in prescription drugs dose formulations and human body fluid. an intensive survey for determination of LSP compiled from the analysis articles printed in numerous pharmaceutical and analytical chemistry journals. This shows that many of the HPLC ways reviewed are supported the measuring of drug in pharmaceutical ingredients (API), biological fluids like body fluid and plasma and that they are applicable for therapeutic observance of drug, for pharmacokinetic purpose.


Prinivil; Spectrophotometry; High pressure liquid chromatography (HPLC)


Prinivil (S)-1-[N2-(1-carboxy-3-phenylpropyl)-L-lysyl]-L-proline dihydrate a lysine simple of enalaprilate, the Prinivil hydrophilic, has a long half-life and no scent and powder having sub-atomic weight of 405.5 and sub-atomic recipe C21H31N3O5.2H2O. It is dissolvable in water and sparingly in methanol, varies from captopril by without the sulfhydryl bunch. It is demonstrated for the treatment of hypertension, heart disappointment and intense myocardial infraction. It is demonstrated as adjunctive treatment in the administration of heart disappointment in patients who are not reacting enough to diuretics and digitalis [1-5]. It is utilized to treat hypertension, Myocardial Infarction (MI), heart disappointment and diabetic nephropathy or retinopathy.

Analytical methods

Assay technique for any drug is incredibly important for pharmaceutical industries and it's continuously fascinating to pick out and develop easy, least time intense, precise, correct and economical technique for the determination of medicine in API pharmaceutical indefinite quantity forms and pathological samples like blood and blood serum [5-20]. Analytical information square measure wont to screen the potential medication in biological samples, support formulation studies, aid within the development of drug syntheses, monitor the (API) bulk prescription drugs and finished product and additionally take a look at final product for unharness.

Analysis Methods of Prinivil

• There are totally different ways of research for Prinivil drug delineated in literature as, combination of various ways or techniques

• Spectro fluorimetric ways for analysis by reaction modifications

• Electrophoresis/capillary natural process ways (HPLC) High Performance Liquid action ways

• UV-visible spectroscopical methods

• Miscellaneous methods

Methods of Analysis

There are various techniques accessible for Prinivil investigation in single part or multi segment plan utilizing spectrophotometry, gas-fluid chromatography slender electrophoresis and polarography. A few high weight fluid chromatography HPLC strategies have been utilized for the investigation of Prinivil in human plasma. HPLC technique for examination of Prinivil in human plasma and pee at 477 nm. Straight quantitative reaction was produced over a fixation scope of 5 ngmL-1 to 200 ngmL-1 and 25 ngmL-1 to 1000 ngmL-1 for plasma and pee tests [21-40]. However, of these ways needed heavy experimental work high consumption of organic solvents and these ways were developed on single column. Our analysis cluster has worked on HPLC ways for the quantitation of inhibitors as ACE inhibitor, angiotensin converting enzyme inhibitor and ACE inhibitor alone and together with fosinopril and nonsteroidal anti-inflammatory in bulk drug, pharmaceutical formulations and bodily fluid [41-48]. Several of them conjointly reported synchronal ways for the determination of assorted ACE inhibitors with co-administered medicine as ACE inhibitor with H2 antagonists, NSAIDs and with statins. Prinivil belongs to antihypertensive drug therefor many ways at the same time discovered of those ACE Inhibitors as well as.

Prinivil belongs to antihypertensive drug therefor many ways at the same time discovered of those ACE Inhibitors as well as ACE inhibitor with H2-receptor antagonists diuretics and statins. angiotensin converting enzyme inhibitor antidepressant drug has been at the same time determined with thiazide and Lasix unremarkably used diuretics, unremarkably used NSAIDs, antidiabetic medicine, sterol lowering agent statins and with antidiabetic drug, glibenclamide and glimepride in bulk, pharmaceutical formulations and human bodily fluid exploitation RP-HPLC [49-56]. Spectrophotometric ways once derivatization of ACE inhibitor and different techniques has been delineated antecedently.


Patients determined to have hypertension are endorsed numerous medicines for treatment which expanding the danger of medication collaborations and reactions. In this article UV spectrophotometry and HPLC strategies for the estimation of Prinivil in (API) dynamic material, definitions and organic specimens are explored alone or in blend with different medications. High weight fluid chromatography HPLC strategies required costly gear, work serious specimen readiness strategy and the individual gifted in chromatographic methods [56-60]. The majority of the HPLC techniques checked on have the potential application to clinical examination of multi-medication pharmacokinetics, drug mix concentrates on furthermore for connections thinks about.


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