pH metric study of binary and ternary complexes of Cu (II) with propiophenone derivatives and amino acids

Author(s): M.B.Swami, B.M.Dhoot, P.V.Dongarkadekar, S.N.Hallale

Proton ligand and Metal ligand formation constant of ternary complexes of the type MLB [Where L = i) L1= 3-chloro,2-hydroxypropiophenone (3-Cl- 2HP) ii) L2 = 2-hydroxypropiophenone (2-HP)] and B = [B1= Hippuric(hip) acid, B2= Glutamic acid (glu) B3=Histidine (hist), B4=Aspartic acid (Asp)] And M = Cu (II) have been determined by potentiometrically in biologically relevant conditions at ionic strength ì = 0.1M NaClO4 the overall stability constant have been evaluated using SCOGS computer program. The complexation equilibria have been derived on the basis of concentration species distribution curve and percentage distribution curve. In all cases primary ligands and secondary ligands are found to be compatible ligands. And there by proving greater stability of ternary complexes as compared to binary ones. The stability of ternary complexes expressed in terms of thermodynamic parameter log k. and Negative values of log k suggest that, the formations of ternary complexes are favorable. And the order of stability constant of ternary system with amino acids for respective primary ligands is. L1= B3> B4 > B2 >B1and L2= B3> B4 > B2> B1.

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