Synthesis, characterization and biological evaluation of bis-bidentate Schiff base metal complexes

Author(s): J.H.Pandya, K.J.Ganatra

A novel series of 4,6-bis(1-(4-substitutedphenylimino)ethyl)benzene-1,3- diols bis-bident Schiff base transition metal complexes, H2L1, H2L2 and H2L3 were synthesized. The Schiff base H2L1, H2L2 and H2L3, ligands were synthesized by the condensation of 4,6-diacetylresorcinol with 4- chloroaniline, 4-flouroaniline and 4-methylaniline respectively. The ligands behave as dibasic bis-bidentates yielding polymeric complexes. The ligands and theirmetal complexes have been characterized by 1H NMR, IR, mass, ESR and elemental analysis. The bonding sites are the azomethine and phenolic oxygen atoms. Themetal complexes exhibit different geometrical arrangements such as square planar, tetrahedral, octahedral and distorted octahedral arrangement. The Schiff base and its newcomplexeswere tested for antibacterial activity against gram positive bacteria; Staphylococcus aureus and gram negative bacteria; Escherichia coli including the resistance bacteria Pseudomonas aeruginosa.

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