Drug Resistance

Drug resistance is a common and serious problem in the treatment of epilepsy, affecting about 1in 3 patients. It is associated with increased morbidity and increased risk of premature mortality. Rational management of drug resistance requires better understanding of its underlying mechanisms. Two main hypotheses have arisen as explanations for resistance: the ‘target’ and the ‘transporter’ hypotheses. It argues that the normal targets of antiepileptic drugs are altered, reducing effectiveness of antiepileptic drugs despite adequate concentrations at those targets. Therefore there are causes that can make drug resistance Over-prescription of antibiotics Patients not finishing the entire antibiotic course, Overuse of antibiotics in livestock and fish farming, Poor infection control in health care settings, Poor hygiene and sanitation, Absence of new antibiotics being discovered.  

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